Microbial Whole Genome Sequencing
Microbial whole genome sequencing is important for precise microbial identification, the generation of complete reference genomes (de novo sequencing), comparative genomic studies (re-sequencing), and genomic exploitation.
Comparative genomic studies can identify individual genetic variations and large scale structural variations within a population for which a reference genome is available. Evolutionary characteristics and phylogenetic relationships can be hence inferred.
Microbial whole genome sequencing provides the possibility of gene finding and annotation. After multiple genes are explained, novel biochemical pathways that may be beneficial for medicine and biotechnology will likely be identified.
For more information and quotation, kindly contact us at NGS@biobasic-asia.com
Bioinformatics Analysis
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For do novo:
- Data Quality Control
- Genome advanced assembly
- Genome survey: genome size, GC distribution, repeat rate
- Genome component analysis: gene structure prediction, repeat sequences, non-coding RNAs
- Gene function annotation
- Data Quality Control
- Alignment with reference
- SNP/InDel calling, annotation and statistics
- SV calling, annotation and statistics
Advantages
- Broad applications: de novosequencing, gene annotations, comparative genomic studies,
evolutionary studies of micro-organisms, etc. - Drug discovery and development: assess the contribution of DNA on pathogenesis and understand the role of mobile elements in drug resistance and transmission
- Cost-effective
- Time-efficient
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